Omada Health to Present Real-World Evidence at ObestiyWeek 2025 Demonstrating Enhanced Outcomes for Current and Former GLP-1 Users
Results suggest sustained, long-term impact of Omada’s program on
weight loss and longer medication persistence
SAN FRANCISCO – November 4, 2025 – Omada Health (Nasdaq: OMDA), the virtual between-visit healthcare provider, announced it will present two posters at ObesityWeek 2025 highlighting the potential impact of Omada’s behavior change program on members currently or previously on GLP-1 medications for weight loss. Together, these analyses suggest that engagement with Omada may enhance results for members who have been on GLP-1s for weight loss, whether they stay on the medication or not.
Previous clinical studies have suggested that sustained weight loss leads to increased long-term health benefits,¹ including the reduction of comorbidities, and persistence on a GLP-1 is associated with greater weight loss.² Those who stop GLP-1s tend to regain the weight they lost³ on the medication. Omada’s analyses demonstrated the clinical benefit of its wraparound lifestyle program on members at various stages of GLP-1 usage.
Omada Increased GLP-1 Medication Persistence and Weight Loss
The first analysis examined GLP-1 persistence rates of 1,124 Omada members enrolled in Omada’s Enhanced GLP-1 Care Track, which provides tailored support to members on their GLP-1 journey.
The analysis evaluated Omada members at 12 and 24 weeks in the program, examining how factors such as program engagement impacted members’ medication persistence. While real-world evidence has previously found lower GLP-1 persistence rates⁴ compared to clinical trials,⁵ Omada’s analysis demonstrated that support via Omada’s program supported enhanced persistence commensurate with increased engagement; 84% of participants stayed on their medication for 24 weeks and lost more weight than those who stopped earlier (12.1% vs. 7.4%). It also found that for every 10 additional engagements per week in the initial 12 weeks, the odds of medication persistence were 54% higher.
“These findings underscore a critical insight in the evolving landscape of obesity treatment. While GLP-1s are powerful tools, our research demonstrates that lifestyle support programs, like Omada, can enhance their effectiveness,” said Sarah Linke, PhD, MPH, Senior Director, Clinical & Translational Research, Omada Health.
Omada Members Maintained Sustained Weight Lost 12 months Post-Discontinuation
The second analysis looked at weight change during the discontinuation phase of the GLP-1 journey. The team conducted a retrospective analysis using prescription claims to examine 816 total Omada members without type 2 diabetes, evaluating them at 6, 9, and/or 12 months after GLP-1 discontinuation. It found that, at one year post-discontinuation, members (n=95) experienced 0.8% average weight change,⁶ compared to 11-12% weight gain typically seen in clinical trials,⁷ with 63.2% maintaining or continuing to lose weight at 12 months.
“As channels to access GLP-1s increase and healthcare costs rise,⁸ every dollar invested into patient care counts,” said Wei-Li Shao, President, Omada Health. “These analyses demonstrated that engagement with Omada may enhance the effectiveness of GLP-1 therapy across all stages of treatment – helping to optimize outcomes and reduce wasted financial investment.”
These studies were completed as part of the Omada Insights Lab ANSWERS (ANalyzing Success of WEight medication with Real-world evidence and Stats) Initiative, which examines and shares real-world data from Omada’s behavior change weight health programs.
Both posters will be presented at The Obesity Society’s ObesityWeek 2025 in Atlanta on November 4-5, 2025.
