Though evidence shows that GLP-1s are highly effective for weight loss, maintaining outcomes after GLP-1 discontinuation can be a struggle. Clinical trials indicate that people often regain a considerable amount of weight after discontinuing their GLP-1, with some studies citing up to an average of 67% of weight regained within a year. Given the substantial cost of GLP‑1 therapies, weight regain after discontinuation not only jeopardizes health outcomes, it also wastes valuable healthcare dollars.
The question everyone seems to be asking is, “Is weight regain post GLP-1s inevitable?” Can virtual lifestyle programs like Omada help people keep the weight off after GLP-1 discontinuation? And what does the real-world evidence show?
The Omada Insights Lab took on these questions by analyzing weight change up to one year after GLP-1 discontinuation. The sample included 816 members without diabetes enrolled in Omada’s Prevention & Weight Health and Hypertension programs. The analysis found that:
-
At 12 months, Omada members largely maintained their weight at GLP-1 discontinuation, with an average 0.8% weight change
-
At 12 months, 63.2% of members maintained or continued to lose weight
-
At 6 and 9 months, Omada members demonstrated 0.03% and 0.6% average weight change, respectively
These findings suggest that Omada can play an integral role in supporting members during important transitions in their GLP-1 journey, including helping members maintain their weight well after GLP-1 discontinuation.
